5-HT1A receptors are inhibitory serotonin receptors involved in mood regulation, anxiety, and neuroprotection.
| Property |
Value |
| Category |
Receptor neurons |
| Neurotransmitter |
Serotonin |
| Receptor |
5-HT1A (HTR1A) |
| Brain Regions |
Hippocampus, raphe nuclei, amygdala, cortex |
- Gi/o coupling: Inhibits adenylate cyclase
- Autoreceptor: Somatodendritic in raphe
- Postsynaptic: Hippocampus, cortex
- Neuroprotection: Anti-apoptotic signaling
- 5-HT1A agonists: Buspirone, tandospirone
- Anxiety: Anxiolytic effects
- SSRIs: Downregulation
- 5-HT1A preservation: Cognitive benefit
- Neuroprotection: Amyloid interaction
- Therapeutic target: Drug development
- 5-HT1A modulation: Anxiolysis
- Benzodiazepine-sparing: Alternative
- Chronic treatment: Desensitization
- Barnes NM, 5-HT1A receptors (2020)
- Polter AM, 5-HT1A receptor function (2017)