5-HT2C receptors regulate feeding, mood, and are targeted by antipsychotic drugs.
| Property |
Value |
| Category |
Serotonin Receptor Neurons |
| Location |
Choroid plexus, Cortex, Hypothalamus |
| Receptor Type |
5-HT2C |
| Signaling |
Gq-coupled, excitatory |
- Family: 5-HT2 (Gq)
- RNA editing: Multiple isoforms
- Dimerization: Functional
- Choroid plexus: CSF
- Hypothalamus: Feeding
- Cortex: Cognition
- Satiety: 5-HT2C signals
- Obesity: 5-HT2C agonists
- Energy: Homeostasis
- Depression: 5-HT2C effects
- Anxiety: 5-HT2C
- Antipsychotics: 5-HT2C antagonism
- Lorcaserin: 5-HT2C agonist
- Weight loss: Clinical
- Withdrawn: Safety concerns
- 5-HT2C: Antipsychotic target
- Atypical: 5-HT2C antagonism
- EPS: Reduction
- Stahl. 5-HT2C receptor (2009)
- Niswender. 5-HT2C (2001)