The cellular prion protein (PrP) is expressed in neurons and involved in neurodegeneration.
| Property |
Value |
| Category |
Prion Proteins |
| Location |
Cell membrane |
| Protein |
PrP (PRNP) |
| Function |
Cell signaling |
- N-terminal: Signal peptide
- C-terminal: GPI anchor
- Copper binding: Octarepeat region
- PrP^C: Normal cellular form
- PrP^Sc: Pathological scrapie form
- Conversion: Misfolding disease
- Synaptic function: PrP at synapses
- Copper ion binding: Antioxidant
- Cell adhesion: Neuronal contacts
- Anti-apoptotic: BCL-2 family
- Oxidative stress: Protection
- Autophagy: Regulation
- Creutzfeldt-Jakob: PrP^Sc deposition
- Fatal familial insomnia: D178N mutation
- Kuru: Horizontal transmission
- PrP and Abeta: Binding studies
- Synaptic dysfunction: PrP mediation
- Therapeutic: PrP-based approaches
- Prusiner. Prions (1997)
- Aguzzi. Prion biology (2009)