Posteromedial Thalamic Nucleus (Pm) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Posteromedial Thalamic Nucleus (PM), also known as the pulvinar or medial pulvinar, is a large thalamic nucleus involved in higher-order visual processing, attention, and integration of multimodal sensory information. It plays crucial roles in cortical communication and cognitive functions. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Cell Type | Thalamocortical projection neurons | [4]
| Location | Posterior thalamus, pulvinar region | [5]
| Marker Genes | CALB1, CB1R, NTRK2, VGluT2 | [6]
| Neurotransmitters | Glutamate (excitatory) | [7]
| Brain Region | Thalamus |
| Taxonomy | ID | Name / Label |
|---|
The PM/pulvinar contains several distinct neuron populations:
The pulvinar is subdivided into:
Key genes expressed in PM neurons include:
The study of Posteromedial Thalamic Nucleus (Pm) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Saalmann YB, Pinsk MA, Wang L, Li X, Kastner S. The pulvinar regulates information flow between cortex and superior colliculus. Nat Neurosci. 2013. ↩︎
Benarroch EE. Pulvinar: associative thalamic relay for multiple modalities. Neurology. 2013. ↩︎
Arend I, Rafal R, Ward R. Spatial and temporal deficits are regionally dissociable in patients with pulvinar lesions. Brain. 2008. ↩︎
Papez JW. A proposed mechanism of emotion. Arch Neurol Psychiatry. 1937. ↩︎
Jones EG. The thalamus. 2007. ↩︎
Shipp S. The functional logic of cortico-pulvinar connections. Philos Trans R Soc Lond B Biol Sci. 2003. ↩︎
Zhou J, Greicius MD, Gennatas ED, et al. Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain. 2010. ↩︎