Posterior Cingulate Cortex (Pcc) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Posterior Cingulate Cortex (PCC) is a central hub in the default mode network, critical for memory retrieval, spatial orientation, and self-referential processing.
| Property | Value |
|---|---|
| Category | Cell Types |
| Brain Region | Posteromedial Cortex |
| Neurotransmitter | Glutamate, GABA |
| Species | Human, Non-human primates, Mouse, Rat |
The PCC contains heterogeneous neuronal populations:
The PCC mediates:
| Input | Output |
|---|---|
| Hippocampus (via entorhinal) | Prefrontal cortex |
| Lateral parietal cortex | Hippocampus |
| Thalamus (pulvinar) | Temporal lobe |
| Anterior cingulate | Subcortical structures |
| Approach | Mechanism | Target |
|---|---|---|
| tDCS/PCC | Neural activation | Cognitive function |
| Mindfulness | PCC regulation | Memory, mood |
| Memory training | PCC plasticity | MCI |
The study of Posterior Cingulate Cortex (Pcc) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Fransson P, Marrelec G. The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis. Neuroimage. 2008;42(3):1178-1184.
[2] Buckner RL, Andrews-Hanna JR, Schacter DK. The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124(1):1-38.
[3] Vogt BA, Laureys S. Posterior cingulate, precuneal and retrosplenial cortices: Cytology and components of the neural network. Cereb Cortex. 2005;15(6):670-682.
[4] Greicius MD, Srivastava G, Reiss AL. Default-mode activity distinguishes Alzheimer's disease from healthy aging. Proc Natl Acad Sci. 2004;101(13):4637-4642.
[5] Zhou J, Greicius MD. Divergent network connectivity changes in behavioural variant FTD and AD. Brain. 2010;133(5):1352-1367.
[6] Minoshima S, Foster NL. Posterior cingulate cortex in AD: Metabolic reduction reflects loss of posterior cingulate function. J Cereb Blood Flow Metab. 1997;17(5):504-512.
[7] Lee J, Kim SH. Posterior cingulate cortex: The emerging role in depression and anxiety disorders. Psychiatry Investig. 2018;15(9):854-863.
[8] Pearson JM, Heilbronner SR. Posterior cingulate cortex: Episodic encoding and retrieval. Neuroscientist. 2011;17(6):618-633.