Nucleus diagonal band cholinergic neurons are a population of basal forebrain neurons that provide the major cholinergic innervation to the hippocampus and limbic structures. These neurons play critical roles in learning, memory, attention, and are prominently affected in Alzheimer's disease.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000108 | cholinergic neuron |
The nucleus diagonal band (NDB) is located in the basal forebrain:
NDB cholinergic neurons project to:
These neurons express:
NDB cholinergic neurons exhibit:
NDB cholinergic projections modulate hippocampal and cortical circuits:
Cholinergic NDB neurons contribute to:
NDB cholinergic neurons are early casualties in AD:
Loss of NDB cholinergic input leads to:
Pharmacological approaches:
Experimental approaches:
Swanson & Cowan. The connections of the septal region. Journal of Comparative Neurology. 1979. ↩︎
Kasa et al. [Cholinergic neurons and their receptors](https://doi.org/10.1016/S0301-0082(96). Progress in Neurobiology. 1997. ↩︎
Jones. Electrophysiological characterization of entorhinal cortex stellate cells. Hippocampus. 1993. ↩︎
Hasselmo. Neuromodulation and the dynamics of memory. Trends in Cognitive Sciences. 2006. ↩︎
Lee et al. Cholinergic modulation of hippocampal theta. Neuroscience. 2005. ↩︎
Coyle et al. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science. 1983. ↩︎
Schliebs & Arendt. The cholinergic system in AD physiology. Journal of Neural Transmission. 2010. ↩︎
Hampel et al. The cholinergic system in AD therapy. Pharmacology & Therapeutics. 2018. ↩︎