This section provides a comprehensive overview of the topic.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0020004 | internal globus pallidus shell projection neuron |
Nucleus Accumbens Shell (Nacshell) Expanded is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
The Nucleus Accumbens Shell (NAcShell) is the outer region of the ventral striatum, playing a critical role in processing emotional and motivational significance of stimuli. Unlike the core region which is more involved in instrumental actions, the shell region is primarily associated with affective processing, emotional responses, and the hedonic qualities of rewards. [2]
](/brain-regions/nucleus-accumbens-core
--ventral-tegmental-area
--amygdala
--mesolimbic-pathway)## Background
The study of Nucleus Accumbens Shell (Nacshell) Expanded has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [3]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [4]
Additional evidence sources: [5] [6] [7]
Berridge KC. The debate over dopamine's role in reward. 2020. ↩︎
Saddoris MP, et al. Nucleus accumbens shell. 2019. ↩︎
Castro DC, Bruchas MR. A motivational and peptidergic gateway. 2021. ↩︎
Wise RA. Dual roles of dopamine in reward and aversion. 2022. ↩︎
Lammel S, et al. Input-specific dopamine pathways. 2020. ↩︎
Volkow ND, et al. The neuroscience of addiction. 2019. ↩︎
Richard JM, et al. Ventral striatal pathways. 2021. ↩︎