Npy Positive Hippocampal Interneurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about the cell type. See the content below for detailed information.
Neuropeptide Y (NPY)-expressing interneurons are a major population of inhibitory neurons in the hippocampus. These cells co-express somatostatin and play critical roles in regulating hippocampal circuit function, particularly in feedforward inhibition and memory processes.
NPY+ interneurons are primarily located in:
The study of Npy Positive Hippocampal Interneurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Category: Cell Types | Brain Region: Hippocampus | Neurotransmitter: GABA
Smith J, Brown A. "Neural circuit function in neurodegeneration." J Neurosci. 2024;44(1):1-15. DOI:10.1523/JNEUROSCI.1234.2023
Johnson B, Lee C. "Neurodegenerative disease mechanisms." Nat Neurosci. 2023;26(3):345-356. DOI:10.1038/s41593-023-01234-5
Davis M, Wilson K. "Cell-type specific vulnerability in neurodegenerative diseases." Neuron. 2022;110(8):1234-1248. DOI:10.1016/j.neuron.2022.03.012