Nodose ganglion neurons are sensory neurons located in the nodose ganglion, a peripheral sensory ganglion of the vagus nerve. They convey visceral sensory information from internal organs to the brainstem.
Nodose Ganglion Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
The nodose ganglion (also known as the inferior vagal ganglion or ganglion nodosum) is a sensory ganglion of the vagus nerve (cranial nerve X) containing the cell bodies of visceral afferent neurons. These neurons are critical for transmitting information from internal organs to the brain and play important roles in autonomic regulation, gut-brain axis communication, and neurodegenerative diseases. [2]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Allen Brain Cell Atlas | Search | Nodose Ganglion Neurons |
| Cell Ontology (CL) | Search | Check classification |
| Human Cell Atlas | Search | Check expression data |
| CellxGene Census | Search | Check cell census |
| Feature | Description | [3]
|---------|-------------| [4]
| Location | Inferior to the jugular ganglion along the vagus nerve | [5]
| Cell types | Pseudounipolar sensory neurons | [6]
| Size | Small to medium neurons (15-30 μm soma diameter) | [7]
| Myelination | Variable - both myelinated and unmyelinated fibers |
Nodose ganglion neurons are classified by:
Nodose ganglion neurons transmit sensory information from:
Single-cell RNA sequencing has identified distinct populations:
Key marker genes:
](/brain-regions/gut-brain-axis)## Background
The study of Nodose Ganglion Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. 2000. ↩︎
Braak H, et al. Staging of brain pathology related to sporadic Parkinson's disease. 2003. ↩︎
Travagli RA, et al. Brainstem circuits regulating gastric function. 2006. ↩︎
Andrews ZB, et al. Nodose ganglion: the sensory gateway to metabolic homeostasis. 2019. ↩︎
Li Z, et al. Vagal afferent neurons in nodose ganglion: role in metabolic regulation. 2021. ↩︎
Kim SH, et al. Alpha-synuclein in the gastrointestinal tract as a potential biomarker for Parkinson's disease. 2022. ↩︎
Furlong TM, et al. Vagal tone in aging and neurodegeneration. 2023. ↩︎