Nociceptin/Orphanin FQ (N/OFQ) neurons modulate pain, mood, and reward.
| Property |
Value |
| Category |
Opioid-like Peptide Neurons |
| Location |
Widespread CNS |
| Cell Type |
N/OFQ neurons |
| Neuropeptide |
Nociceptin |
¶ Genes and Receptors
- PNOC: Prepronociceptin gene
- NOP: Nociceptin receptor
- Release: Dense core vesicles
- Hippocampus: High density
- Amygdala: Stress responses
- Hypothalamus: Homeostasis
- Bidirectional: Pro- and anti-nociceptive
- Stress-induced analgesia: N/OFQ role
- Tolerance: Opioid system interactions
¶ Mood and Reward
- Anxiety: Anxiogenic effects
- Depression: N/OFQ in mood
- Reward: VTA modulation
- NOP antagonists: Anxiolytic potential
- Stress: N/OFQ in stress response
- Therapeutic target: NOP modulation
- N/OFQ and reward: Drug-seeking
- Alcohol: N/OFQ interactions
- Treatment: NOP antagonists
- Mollereau. Nociceptin (1994)
- Lambert. Nociceptin system (2008)