Nicotinic acetylcholine receptor (nAChR) α9α10 receptor neurons are important in the neurobiology of Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. This page provides detailed information about their structure, function, and role in disease processes.
Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons express the nAChR α9α10 receptor, a ligand-gated ion channel involved in:
These receptors are unique among nicotinic receptors as they can form functional channels composed of α9 and α10 subunits. They are expressed in various brain regions including the hippocampus, basal forebrain, and cochlear nucleus.
In neurodegenerative diseases, α9α10 nAChRs may represent therapeutic targets as their activation can provide neuroprotection against excitotoxicity, oxidative stress, and neuroinflammation.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000197 | sensory receptor cell |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0000197 | sensory receptor cell | Medium |
| Cell Ontology | CL:0004117 | retinal ganglion cell A | Medium |
| Property | Value |
|---|---|
| Receptor Type | nAChR α9α10 |
| Family | Nicotinic acetylcholine |
| Signaling Mechanism | Ligand-gated ion channel, Ca2+ permeable |
| Primary Location | Cochlea, vestibular system, dorsal root ganglia |
Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons are involved in Auditory processing, pain modulation. These neurons express the nAChR α9α10 receptor which ligand-gated ion channel, ca2+ permeable. The receptor's location in cochlea, vestibular system, dorsal root ganglia allows it to modulate neurotransmission and cellular signaling in key brain regions.
The nAChR α9α10 receptor signals through ligand-gated ion channel, ca2+ permeable. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Hearing loss, chronic pain syndromes. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
The nAChR α9α10 receptor is a target for drug development in:
Neurological disorders
Neuropsychiatric conditions
Neurodegenerative diseases
Receptor Neurons
Neurotransmitter Systemsmechanisms/cholinergic-hypothesis-ad)
Nicotinic acetylcholine Signaling
The study of Nicotinic Acetylcholine Alpha 9 Alpha 10 Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.