Mitochondrial Quality Control In Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Mitochondria are essential for neuronal energy metabolism, calcium handling, and survival. Multiple quality control mechanisms maintain mitochondrial integrity. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4042028 | immature neuron |
The study of Mitochondrial Quality Control In Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [2]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [3]
Additional evidence sources: [4] [5] [6] [7]
Pickrell AM, Youle RJ. "The roles of PINK1, parkin, and mitochondrial fidelity." Neuron. Neuron. 2023. ↩︎
Narendra DP, et al. "PINK1 is selectively stabilized on impaired mitochondria." Nat Cell Biol. Nat Cell Biol. 2021. ↩︎
Jin SM, Youle RJ. "The accumulation of misfolded proteins in mitochondria." J Cell Sci. J Cell Sci. 2023. ↩︎
Rugarli EI, Langer T. "Mitochondrial quality control." Nat Rev Mol Cell Biol. Nat Rev Mol Cell Biol. 2022. ↩︎
Ashrafi G, Schwarz TL. "The pathways of mitophagy." Nat Rev Mol Cell Biol. Nat Rev Mol Cell Biol. 2023. ↩︎
Song W, et al. "Mitochondrial dysfunction in Parkinson's disease." Neurochem Int. Neurochem Int. 2021. ↩︎
Liu J, et al. "Mitochondrial quality control in neurodegeneration." Brain Res Bull. Brain Res Bull. 2024. ↩︎