Microglia In Parkinson Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
In Parkinson's disease, microglial activation is a hallmark pathological feature. The substantia nigra pars compacta shows dense microglial infiltration surrounding dopaminergic neurons, creating a chronic neuroinflammatory environment[1]. This chronic activation contributes to progressive dopaminergic neuron loss through multiple mechanisms including oxidative stress, pro-inflammatory cytokine release, and complement-mediated synapse elimination[2].
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000129 | microglial cell |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0000129 | microglial cell | Exact |
The study of Microglia In Parkinson Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gerhard A, Pavese N, Hotton G, et al. In vivo imaging of microglial activation in Parkinson's disease. 2010. ↩︎
Tansey MG, Goldberg MS. Neuroinflammation in Parkinson's disease: role of microglia and complement system. 2007. ↩︎
Pisanu A, Cacciotto A, Cacciola G, et al. Microglial activation in alpha-synucleinopathies. 2014. ↩︎
Gaillard M, Keller M. Microglial activation and dopaminergic neurodegeneration. 2014. ↩︎
Sule L, Harrison B, Happe S. Neuroinflammation and oxidative stress in Parkinson's disease. 2009. ↩︎
Cunningham C, Hennessy E. Neuroinflammation and neurodegeneration in Parkinson's disease. 2013. ↩︎
Choi I, Wang M, Yoo S, et al. Neuroinflammation in alpha-synucleinopathies. 2020. ↩︎
Whitton PS. Inflammation as a causative factor in Parkinson's disease. 2007. ↩︎
Caggiu E, Arru G, Piras F, et al. TSPO PET imaging in Parkinson's disease. 2019. ↩︎
McGeer PL, Itagaki K, Boyt BE, McGeer EG. Location of microglia in postmortem brain in normal aging and Parkinson's disease. Neurology. 1988. ↩︎
Kelley KA, Ho L, Winger D, et al. Microglial activation in a mouse model of Parkinson's disease. 2019. ↩︎
Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection?. 2009. ↩︎