mGluR8 is a group III metabotropic glutamate receptor involved in anxiety and sensory processing.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Olfactory bulb, Cortex, Hippocampus |
| Receptor Type |
mGluR8 (GRM8) |
| Signaling |
Gi-coupled, inhibitory |
- Family: Group III mGluRs
- G protein: Gi/o
- Low efficacy: Agonist responses
- Olfactory bulb: Mitral cells
- Cortex: Pyramidal neurons
- Hippocampus: Dentate gyrus
- Olfaction: Mitral cell function
- Sensory gating: Cortical processing
- Perception: Role unclear
- Anxiety: Anxiogenic effects
- Fear: Extinction learning
- Exploration: Novelty seeking
- mGluR8: Anxiogenic
- Fear extinction: Impaired
- Therapeutic: mGluR8 agonists
- GRM8: Genetic association
- Sensory processing: Altered
- Therapeutic: Potential target
- Kelley et al., mGluR8 in anxiety (2004)
- Corti et al., mGluR8 functions (2002)