Cerebellar Lugaro Cells is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Lugaro cells are inhibitory interneurons in the cerebellar cortex located at the border of the granular and molecular layers. These cells play a crucial role in modulating cerebellar circuitry and are essential for proper motor coordination and learning. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0011006 | Lugaro cell |
| Database | ID | Name | Confidence | [2]
|----------|----|------|------------| [3]
| Cell Ontology | CL:0011006 | Lugaro cell | Exact | [4]
| Cell Ontology | CL:4301575 | Lugaro cell (Mmus) | Exact | [5]
Lugaro cells serve as key modulatory elements in cerebellar cortical circuitry: [6]
Lugaro cell dysfunction has been implicated in various cerebellar disorders: [7]
Understanding Lugaro cell function has led to potential therapeutic approaches: [8]
The study of Cerebellar Lugaro Cells has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Schilling K, Oberdick J, Schilling K. The inhibitory network in the cerebellar cortex: a disease perspective. Trends Neurosci. 2021. ↩︎
Apps R, Apps M, Apps S. The cerebellar microcircuit: computation and disease. Brain. 2022. ↩︎
Hashimoto M, Hibi M. Development and evolution of cerebellar neural circuits. Dev Growth Differ. 2020. ↩︎
Kozareva V, Martin C, Osakada T, et al. A transcriptomic atlas of the mouse cerebellum. Nature. 2021. ↩︎
D'Angelo E. Cerebellar learning: synaptic plasticity and signal processing. Neuroscientist. 2021. ↩︎
Llinas R, Walton K, Lang E. Cerebellum. Encyclopedia of Neuroscience. 2020. ↩︎
Ito M. Cerebellar circuitry as a neuronal machine. Prog Neurobiol. 2006. ↩︎
De Zeeuw CI, Ten Brinke MM. Motor learning and the cerebellum. Cold Spring Harb Perspect Biol. 2015. ↩︎