Intercalated Amygdala Nucleus is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The intercalated amygdala nuclei (or intercalated cell masses) are clusters of GABAergic neurons located between the basolateral and centromedial amygdala complexes. These nuclei serve as critical inhibitory gatekeepers, modulating amygdala output and fear memory processes Citation 1. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0005010 | renal intercalated cell |
| Database | ID | Name | Confidence | [2]
|----------|----|------|------------| [3]
| Cell Ontology | CL:0005010 | renal intercalated cell | Exact | [4]
The intercalated nuclei form a sheet-like collection of small neurons positioned at the interface between: [5]
The intercalated nuclei are essential for: [6]
The study of Intercalated Amygdala Nucleus has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [7]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [8]
Additional evidence sources: [9] [10] [11] [12] [13] [14]
McDonald AJ. Cytoarchitecture of the central amygdala. Journal of Comparative Neurology. 1982. ↩︎
Royer S, et al. Control of centromedial amygdala by prefrontal cortex. Cerebral Cortex. 2000. ↩︎
Petrovich GD, et al. Convergence of limbic and sensory inputs. Journal of Comparative Neurology. 2001. ↩︎
Likhtik E, et al. Prefrontal cortex control of the amygdala. Journal of Neuroscience. 2005. ↩︎
Quirk GJ, Mueller D. Neural mechanisms of extinction learning. Neuropsychopharmacology. 2008. ↩︎
Maren S, Quirk GJ. Neuronal signalling of fear memory. Nature Reviews Neuroscience. 2004. ↩︎
Herry C, et al. Neuronal circuits of fear extinction. Nature. 2010. ↩︎
Aggleton JP. Multiple memory systems of the amygdala. Nature Reviews Neuroscience. 2010. ↩︎
Poewe W, et al. Non-motor symptoms in Parkinson disease. Nature Reviews Neurology. 2017. ↩︎
Rascovsky K, et al. Diagnostic criteria for FTD. Brain. 2011. ↩︎
Luth A, et al. Adaptive plasticity of fear extinction. Neuropsychopharmacology. 2016. ↩︎
Davis M, et al. Effects of d-cycloserine on fear extinction. Psychopharmacology. 1999. ↩︎
Tovote P, et al. Amygdala circuits for fear and reward. Neuron. 2016. ↩︎
Wolff SB, et al. Amygdala intercalated neurons gate fear. Nature. 2014. ↩︎