Insulin signaling in the brain regulates food intake, cognition, and synaptic plasticity.
| Property |
Value |
| Category |
Metabolic Hormone Neurons |
| Location |
Hypothalamus, Cortex, Hippocampus |
| Hormone |
Insulin (INS) |
| Receptors |
IR (Insulin Receptor) |
- Insulin: 51 amino acids (A, B chains)
- Proinsulin: Precursor
- Pancreatic beta cells: Production
- IR-A/B: Isoforms
- Hybrid receptors: IGF-1R
- Neuronal IR: Brain-specific
- Food intake: Satiety
- Glucose: Homeostasis
- Energy: Balance
- Synaptic plasticity: LTP/LTD
- Learning: Memory formation
- Neuronal survival: Neuroprotection
- Insulin resistance: Brain effects
- Cognitive decline: Diabetes link
- Therapeutic: Intranasal insulin
- Insulin signaling: Brain insulin resistance
- AD: Type 3 diabetes hypothesis
- Therapeutic: Insulin therapy
- [. Insulin in brainBennett)](https://doi.org/10. (19781016/0006-8993(78)90467-0)
- Arnold. Brain insulin (2018)