| Horizontal Diagonal Band GABAergic Neurons | |
|---|---|
| Lineage | Neuron > Forebrain > Diagonal Band |
| Markers | GAD1, GAD2, SST |
| Brain Regions | Horizontal Diagonal Band |
| Disease Vulnerability | Alzheimer's Disease |
Horizontal Diagonal Band Gabaergic Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Horizontal Diagonal Band GABAergic Neurons are a specialized cell type classified within the Neuron > Forebrain > Diagonal Band.[1] These cells are primarily found in Horizontal Diagonal Band and are characterized by expression of marker genes including GAD1, GAD2, SST. They are selectively vulnerable in Alzheimer's Disease.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000560 | band form neutrophil |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0000560 | band form neutrophil | Medium |
| Cell Ontology | CL:0000617 | GABAergic neuron | Medium |
| Cell Ontology | CL:0000745 | retina horizontal cell | Medium |
Horizontal Diagonal Band GABAergic Neurons are identified by the expression of the following key marker genes:
GAD1, GAD2, SST
These markers are used for immunohistochemical identification and single-cell RNA sequencing classification.
Horizontal Diagonal Band GABAergic Neurons play essential roles in neural circuits and brain function. They are found in the following brain regions:
Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.
Horizontal Diagonal Band GABAergic Neurons show selective vulnerability in the following neurodegenerative conditions:
Alzheimer's disease
The selective vulnerability of these cells is an active area of research.
Cell-type-informed therapeutics aim to either protect vulnerable populations directly or modulate surrounding microenvironments that drive degeneration.
Záborszky L, et al. "Neurons in the basal forebrain cholinergic system." Brain Res Rev. 2023. ↩︎