H4 receptors are involved in immune modulation and may play roles in neuroinflammation.
| Property |
Value |
| Category |
Histamine Receptor Neurons |
| Location |
Brain, Immune cells |
| Receptor Type |
H4 histamine receptor |
| Signaling |
Gi-coupled, inhibitory |
- Family: H4 histamine
- G protein: Gi/o
- cAMP: Decreases
- Brain: Lower than H1-H2
- Immune cells: Mast cells, eosinophils
- Peripheral: Hematopoietic
- Chemotaxis: Eosinophil
- Mast cell: Degranulation
- Inflammation: Modulation
- Microglia: H4 effects
- Neuroinflammation: Role unclear
- Therapeutic: Targeting
- H4 antagonists: Allergy
- Inflammation: Autoimmune
- Therapeutic: Trials ongoing
- MS: H4 potential
- AD: H4 in
- Therapeutic: Unknown
- Zampeli. H4 histamine receptor (2009)
- Thurmond. H4 receptor (2008)