Neurons expressing histamine H1 receptors mediate the wake-promoting effects of histamine.
| Property |
Value |
| Category |
Histamine Receptor Neurons |
| Location |
Widespread CNS |
| Receptor Type |
H1 histamine receptor |
| Signaling |
Gq-coupled, excitatory |
- Thalamus: arousal nuclei
- Cortex: Layer 4-6
- Hypothalamus: wake-promoting areas
- PLC activation: Phospholipase C
- IP3/DAG: Second messengers
- Calcium: Intracellular release
- Wakefulness: H1 activation promotes wake
- Anti-histamines: Sedation via H1 block
- Sleep-wake: Histaminergic tone
- Attention: H1 in attention
- Learning: Histamine modulation
- Memory: Consolidation effects
- Insomnia: H1 antagonists
- Narcolepsy: H1 agonists
- Sleep architecture: H1 effects
- Schizophrenia: H1 alterations
- Depression: H1 in mood
- Anxiety: H1 mechanisms
- Haas. Histamine H1 receptors (2008)
- Brown. Histamine in brain (2001)