Hippocampal Ca4 Neurons is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The CA4 region of the hippocampus is the most proximal subfield to the dentate gyrus, forming a critical node in the trisynaptic circuit. CA4 neurons receive input from the dentate gyrus mossy fibers and project to CA3 pyramidal neurons, playing essential roles in memory consolidation and pattern completion. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4023061 | hippocampal CA4 neuron |
| Database | ID | Name | Confidence | [2]
|----------|----|------|------------| [3]
| Cell Ontology | CL:4023061 | hippocampal CA4 neuron | Exact |
CA4 is located in the hippocampal formation, bordered by the dentate gyrus hilus medially and the CA3 region laterally. The region contains:
Key markers for CA4 neurons include:
CA4 neurons contribute to:
CA4 neurons are affected early in AD progression:
CA4 is particularly vulnerable in temporal lobe epilepsy:
The study of Hippocampal Ca4 Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hunsaker MR, et al. The importance of CA4 in memory encoding. (2008). 2008. ↩︎
Treves A, et al. CA3-CA4 circuit function in memory. (2008). 2008. ↩︎
Yang Y, et al. Mossy fiber synaptic plasticity in CA4. (2013). 2013. ↩︎