Hippocampal Basket Cells In Neurodegeneration is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Hippocampal basket cells are GABAergic interneurons that form inhibitory synapses around the soma of pyramidal cells. These cells play crucial roles in hippocampal circuit function and have been implicated in the cognitive deficits observed in various neurodegenerative diseases. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000118 | basket cell |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0000118 | basket cell | Exact |
| Cell Ontology | CL:2000027 | cerebellar basket cell | Exact |
Basket cells in AD show:
| Component | Change in Disease | Effect |
|---|---|---|
| GAD65/67 | Reduced | Less GABA |
| GABA-A α1 | Altered subunits | Changed inhibition |
| PV expression | Decreased | Cell vulnerability |
The study of Hippocampal Basket Cells In Neurodegeneration has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.