GPER (G-Protein Coupled Estrogen Receptor) Neurons are neurons expressing the GPER (GPR30) receptor, a member of the Estrogen membrane receptor family. These receptor neurons play crucial roles in rapid estrogen signaling, neuroprotection and are implicated in various neurological and neurodegenerative conditions.
| Property | Value |
|---|---|
| Receptor Type | GPER (GPR30) |
| Family | Estrogen membrane |
| Signaling Mechanism | G protein-coupled, rapid signaling via EGFR transactivation |
| Primary Location | Hippocampus, cortex, basal ganglia, cerebellum |
GPER (G-Protein Coupled Estrogen Receptor) Neurons are involved in Rapid estrogen signaling, neuroprotection. These neurons express the GPER (GPR30) receptor which g protein-coupled, rapid signaling via egfr transactivation. The receptor's location in hippocampus, cortex, basal ganglia, cerebellum allows it to modulate neurotransmission and cellular signaling in key brain regions.
The GPER (GPR30) receptor signals through g protein-coupled, rapid signaling via egfr transactivation. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Alzheimer's disease, metabolic disorders. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
The GPER (GPR30) receptor is a target for drug development in: