EMAP (EMAP-Like 4), also known as EEF1E1 (Eukaryotic Translation Elongation Factor 1 Epsilon 1), is a protein involved in protein synthesis and cell survival pathways. It functions as a component of the eukaryotic translation elongation factor complex and has been implicated in various cellular processes relevant to neurodegeneration.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000164 | enteroendocrine cell |
The EMAP gene encodes a protein that, despite its name, is not directly homologous to the original EMAP (endothelial microtubule-associated protein) family. Instead, it participates in translational regulation and has connections to p53-mediated apoptosis pathways. The gene is located on chromosome 6p21.1 [1].
EMAP/EEF1E1 contains:
As part of the eEF1 complex:
EMAP regulates cell death through:
EMAP affects mitochondria:
EMAP participates in:
Targeting EMAP pathways offers:
EMAP as a biomarker:
EMAP polymorphisms studied in:
Mouse model studies reveal:
Understanding EMAP's multifaceted roles may lead to:
Novel neuroprotective strategies
Biomarkers for neuronal injury
Combination therapy approaches
Neurons Major brain cell type
Glia — Suppor- Alzheimer's DiseaseAlzhe- Parkinson's Diseased neurodegenerative disease
Parkinson's Disease Related neurodegenerative disease
Matsumoto et al. EEF1E1 identification and function (2005). 2005. ↩︎
Browne et al. [eEF1 complex in translation (2002)](https://doi.org/10.1016/S0076-6879(02). 2002. ↩︎
Sze et al. Translation factors in neurodegeneration (2017). 2017. ↩︎
Liu et al. EEF1E1 in apoptosis (2010). 2010. ↩︎