Enteric Glial Cells In Parkinson Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
| Property | Value | [^1]
|----------|-------| [1]
| Category | Enteric Nervous System | [2]
| Location | Gastrointestinal tract | [3]
| Cell Type | Enteric glial cells (EGCs) | [4]
| Markers | GFAP, S100B, Sox10 | [5]
| Lineage | Neural crest-derived | [6]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0007011 | enteric neuron |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0007011 | enteric neuron | Exact |
| Cell Ontology | CL:4040002 | enteroglial cell | Exact |
The ENS contains two main glial cell populations:
EGCs communicate with enteric neurons through:
The Enteric Nervous System as Initiation Site:
Enteric glial alpha-syn → Vagal nerve uptake → Dorsal motor nucleus →
Nigral dopaminergic neurons → Lewy body formation
| Symptom | Prevalence | Mechanism |
|---|---|---|
| Constipation | 60-80% | EGC dysfunction, neuronal loss |
| Gastroparesis | 30-50% | Enteric neuropathy |
| Small intestinal bacterial overgrowth | 25-30% | motility disorders |
| Dysphagia | 20-40% | Esophageal glial changes |
Microbiome Interactions:
Immune Activation:
](https://doi.org/10.1002/mds.26312). 2015.
VanKampen JM, et al. The gut-brain axis in Parkinson's disease: Implications for non-motor symptoms. 2020. ↩︎
Depommier C, et al. The gut virome in Parkinson's disease. 2023. ↩︎
Grella CE, et al. Enteric glia as a contributor to Parkinson's disease pathogenesis. 2022. ↩︎
Böttner M, et al. Interplay between alpha-synuclein and enteric glia in Parkinson's disease. 2023. ↩︎
Challis C, et al. Gut-seeded alpha-synuclein fibrils propagate through the peripheral nervous system. 2020. ↩︎
Shamash S, et al. The gastrointestinal tract in Parkinson's disease. 2022. ↩︎