Enteric Glial Cells In Parkinson Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
| Property | Value |
|---|---|
| Category | Enteric Nervous System |
| Location | Gastrointestinal tract |
| Cell Type | Enteric glial cells (EGCs) |
| Markers | GFAP, S100B, Sox10 |
| Lineage | Neural crest-derived |
The ENS contains two main glial cell populations:
EGCs communicate with enteric neurons through:
The Enteric Nervous System as Initiation Site:
Enteric glial alpha-syn → Vagal nerve uptake → Dorsal motor nucleus →
Nigral dopaminergic neurons → Lewy body formation
| Symptom | Prevalence | Mechanism |
|---|---|---|
| Constipation | 60-80% | EGC dysfunction, neuronal loss |
| Gastroparesis | 30-50% | Enteric neuropathy |
| Small intestinal bacterial overgrowth | 25-30% | motility disorders |
| Dysphagia | 20-40% | Esophageal glial changes |
Microbiome-EGC Interactions:
Immune Activation:
The study of Enteric Glial Cells In Parkinson Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Clairembault T, et al. Enteric glia: A new player in Parkinson's disease. Mov Disord. 2015;30(10):1366-1376. DOI:10.1002/mds.26312
VanKampen JM, et al. The gut-brain axis in Parkinson's disease: Implications for non-motor symptoms. J Parkinsons Dis. 2020;10(s1):S15-S22. DOI:10.3233/JPD-202138
Depommier C, et al. The gut virome in Parkinson's disease. J Parkinsons Dis. 2023;13(2):169-183. DOI:10.3233/JPD-225137
Grella CE, et al. Enteric glia as a contributor to Parkinson's disease pathogenesis. Front Cell Neurosci. 2022;16:1058944. DOI:10.3389/fncel.2022.1058944
Böttner M, et al. Interplay between alpha-synuclein and enteric glia in Parkinson's disease. Neurobiol Dis. 2023;177:105004. DOI:10.1016/j.nbd.2022.105004
Challis C, et al. Gut-seeded alpha-synuclein fibrils propagate through the peripheral nervous system. Nat Neurosci. 2020;23(3):327-336. DOI:10.1038/s41593-020-0597-6
Shamash S, et al. The gastrointestinal tract in Parkinson's disease. Nat Rev Gastroenterol Hepatol. 2022;19(2):111-126. DOI:10.1038/s41575-021-00528-z