Double bouquet cells are GABAergic interneurons found in the cerebral cortex. They are characterized by their distinctive axon morphology with bundles of descending axons that give rise to the "double bouquet" appearance.
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4023159 | double bouquet cell |
| Database | ID | Name | Confidence | [1]
|----------|----|------|------------| [2]
| Cell Ontology | CL:4023159 | double bouquet cell | Exact | [3]
Double Bouquet Cells is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [4]
Double bouquet cells (also called double-bouquet neurons or bitufted neurons) are a distinctive type of cortical GABAergic interneuron characterized by their unique axonal arborization pattern. They play crucial roles in cortical microcircuit organization and information processing. [5]
| Feature | Description | [6]
|---------|-------------|
| Cell body size | Small to medium (10-15 μm soma diameter) |
| Dendrites | Bitufted, vertically oriented |
| Axon | Vertically oriented bundle forming "double bouquet" |
| Axon cartridges | Bundle-like terminations targeting pyramidal neuron somata |
Double bouquet cells belong to the non-fast-spiking interneuron group and are characterized by:
Single-cell RNA sequencing reveals distinct molecular signatures:
Key genes:
The study of Double Bouquet Cells has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Wang Y, et al. Anatomical and physiological properties of double bouquet cells in monkey prefrontal cortex. 2022. ↩︎
Konno A, et al. Classification of nonpyramidal neurons in monkey neocortex. 2020. ↩︎
Somogyi P, et al. Double bouquet cell: a neuron interneuron specialized to provide columnar inhibition. 1998. ↩︎
Tamás G, et al. Activity-specificity of inhibitory circuits in the neocortex. 2017. ↩︎
Favorov OV, et al. Loss of calbindin-positive interneurons in Alzheimer's disease. 2019. ↩︎
Marin O, et al. Interneuron dysfunction in psychiatric disorders. 2022. ↩︎