D3 receptors are enriched in the mesolimbic system and regulate reward and motivation.
| Property |
Value |
| Category |
Dopamine Receptor Neurons |
| Location |
Nucleus accumbens, Ventral striatum |
| Receptor Type |
D3 (DRD3) |
| Signaling |
Gi-coupled, inhibitory |
- Family: D2-like (D2, D3, D4)
- G protein: Gi/o
- Similarity: D2 homology
- Nucleus accumbens: Shell
- Islands of Calleja: High
- Ventral striatum: Reward
- Motivation: D3 effects
- Addiction: D3 role
- Reinforcement: Drug seeking
- Nigrostriatal: Lower D3
- Therapeutic: D3 partial agonists
- D3 antagonists: Anti-craving
- Drug seeking: D3 role
- Therapeutic: Targeting
- D3 agonists: Motor effects
- Pramipexole: D3 preferential
- Dyskinesia: D3 involvement
- Sokoloff. D3 receptor discovery (1990)
- Heidbreder. D3 in addiction (2005)