D1 receptor-expressing neurons mediate the rewarding and motor-activating effects of dopamine.
| Property |
Value |
| Category |
Dopamine Receptor Neurons |
| Location |
Striatum, Cortex, Nucleus Accumbens |
| Receptor Type |
D1 (DRD1) |
| Signaling |
Gs-coupled, excitatory |
- Family: D1-like (D1, D5)
- G protein: Gs/olf
- cAMP: Increases intracellular cAMP
- Striatum: Direct pathway neurons (D1-MSNs)
- Cortex: Layer 2/3 pyramidal neurons
- Nucleus Accumbens: Reward processing
- Adenylate cyclase: Activation
- cAMP: Protein kinase A activation
- CREB: Gene transcription
- Durrent: Increased firing
- NMDA: Potentiated responses
- AMPA: Enhanced transmission
- Direct pathway: D1-MSNs initiate movement
- Bradykinesia: Loss in PD
- Dyskinesia: Dopamine-induced
¶ Reward and Motivation
- Nucleus accumbens: Reward prediction
- Drug addiction: D1 activation
- Natural rewards: Food, sex
- D1 agonists: Therapeutic potential
- D1 dysfunction: Motor symptoms
- L-DOPA: Affects D1 signaling
- D1 hypothesis: Hypofunction theory
- D1 antagonists: Cognitive effects
- Therapeutic: D1 modulation
- Missale. D1 receptor family (1998)
- Sibley. Dopamine receptors (1995)