Dna Damage And Repair In Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Neurons are particularly vulnerable to DNA damage due to their post-mitotic state and high metabolic activity. Accumulated DNA damage contributes to aging and neurodegeneration. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4042028 | immature neuron |
The study of Dna Damage And Repair In Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [2]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [3]
Additional evidence sources: [4] [5] [6] [7]
Suberbielle E, et al. "Physiological neuronal DNA repair." Nat Neurosci. Nat Neurosci. 2022. ↩︎
Khanna A, et al. "DNA damage and repair in neurons." J Neurochem. J Neurochem. 2023. ↩︎
Sancar A, et al. "DNA repair and mutagenesis." Annu Rev Biochem. Annu Rev Biochem. 2021. ↩︎
Fishel ML, et al. "DNA repair in the aging brain." Neurochem Int. Neurochem Int. 2021. ↩︎
McKinnon PJ. "DNA repair in the nervous system." Genome Res. Genome Res. 2023. ↩︎
Katyal S, et al. "DNA double-strand break repair in neurons." Cell Death Differ. Cell Death Differ. 2022. ↩︎
Bohr VA. "DNA repair and neurodegeneration." Free Radic Biol Med. Free Radic Biol Med. 2023. ↩︎