Dentate Gyrus Granule Cells Expanded is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about the cell type. See the content below for detailed information on morphology, function, and disease associations.
Dentate gyrus granule cells are the principal excitatory neurons of the dentate gyrus. They receive input from the entorhinal cortex via the perforant path and project mossy fibers to CA3. They are critical for pattern separation and memory encoding.
The study of Dentate Gyrus Granule Cells Expanded has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Sorrells SF, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555(7696):377-381. DOI:10.1038/nature25975 ↩︎
Yassa MA, Stark CE. Pattern separation in the human dentate gyrus. Curr Opin Neurobiol. 2011;21(5):730-739. DOI:10.1016/j.conb.2011.06.007 ↩︎
Parent JM, et al. Dentate granule cell neurogenesis is increased in seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci. 1997;17(10):3727-3738. DOI:10.1523/JNEUROSCI.17-10-03727.1997 ↩︎