Deep brain stimulation (DBS) modulates specific neuronal populations to treat movement and psychiatric disorders.
DBS involves implanted electrodes delivering electrical pulses to specific brain targets. Effects involve modulation of neuronal activity rather than inhibition.
- Primary target for PD
- Glutamatergic neurons
- Hyperactive in PD
- Motor cortex effects
- Primary target for dystonia
- GABAergic output
- Motor thalamus effects
- Target for essential tremor
- Thalamocortical neurons
- Relay to motor cortex
- Target for epilepsy
- Papez circuit
- Memory effects
- Action potential generation
- Axonal activation
- Synaptic modulation
- Basal ganglia modulation
- Thalamocortical circuits
- Distributed effects
- STN or GPi target
- Motor symptoms
- Levodopa-induced dyskinesias
- VIM target
- Tremor suppression
- Quality of life
- GPi target
- Variable response
- Often young patients
- Anterior capsule
- OCD symptoms
- Refractory cases
- ANT target
- Seizure reduction
- Refractory cases
- DBS mechanisms (2022)
- DBS for movement disorders (2021)