DBH neurons convert dopamine to norepinephrine and are the noradrenergic neurons.
| Property |
Value |
| Category |
Catecholamine Neurons** |
| **Location coeruleus, Brainstem |
|
| Enzyme |
Dopamine beta-hydroxylase |
| Transmitter |
Norepinephrine |
- DBH: Dopamine beta-hydroxylase
- Ascorbate: Cofactor
- Copper: Cofactor requirement
- Tyrosine: Starting point
- DOPA: Intermediate
- Dopamine: Substrate
- Main source: Central norepinephrine
- Projections: Widespread
- Wakefulness: Arousal
- A1/A2: Cell groups
- Spinal cord: Sympathetic
- Lateral tegmentum: A7, A8
- Wakefulness: LC activation
- Attention: Focus
- Stress: NE response
- Blood pressure: Vasoconstriction
- Heart rate: Modulation
- Metabolism: NE effects
- DBH: Genetic variants
- Norepinephrine: Attention
- Therapeutic: NDRIs
- Norepinephrine: Mood
- SNRIs: Norepinephrine
- Therapeutic: NE targeting
- Kaufman. DBH enzyme (1987)
- Berridge. Locus coeruleus (2012)