D2, D3, and D4 receptors are D2-like dopamine receptors that are inhibitory and mediate motor control and reward.
| Property |
Value |
| Category |
Dopamine Receptor Neurons |
| Location |
Striatum, VTA, PFC |
| Receptor Type |
D2 (DRD2), D3 (DRD3), D4 (DRD4) |
| Signaling |
Gi-coupled, inhibitory |
- Family: D2-like (D2, D3, D4)
- G protein: Gi/o
- cAMP: Decreases
- Striatum: Indirect pathway
- VTA: Dopamine neurons
- Cortex: D4 expression
- Movement: Inhibition
- Bradykinesia: D2 agonism
- Dyskinesia: D2 modulation
- D2: Reward prediction error
- Addiction: Critical
- Aversion: D3 role
- D2 agonists: Pramipexole
- Motor symptoms: Treatment
- Impulse control: Side effect
- D2 antagonists: Antipsychotics
- Positive symptoms: Treatment
- EPS: Side effect
- Beaulieu et al., D2 signaling (2009)
- Sokoloff et al., D3 receptor (2006)