ChAT produces acetylcholine and is the definitive marker for cholinergic neurons.
| Property |
Value |
| Category |
Cholinergic Neurons |
| Location |
Basal forebrain, Brainstem |
| Enzyme |
Choline acetyltransferase |
| Transmitter |
Acetylcholine |
- ChAT: Choline acetyltransferase
- Acetyl-CoA: Acetyl donor
- Choline: Substrate
- Common ChAT: Most neurons
- pChAT: Peripheral
- VAChT: Coupled transporter
- NBM: Nucleus basalis of Meynert
- DB: Diagonal band
- SEPT: Septal nuclei
- Pedunculopontine: REM sleep
- Medial habenula: Reward
- Motor neurons: Spinal
- Memory: Basal forebrain
- Attention: Cortical activation
- Learning: Cholinergic
- Motor control: Brainstem
- REM sleep: PPN
- Parkinson's: Cholinergic
- ChAT loss: Early marker
- Cognitive decline: Cholinergic
- Therapeutic: AChE inhibitors
- Cholinergic: Cognitive decline
- Dementia: Lewy bodies
- Therapeutic: Targeting
- Oda. ChAT discovery (1999)
- Woolf. Cholinergic system (1991)