Cerebellar Circuit Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The cerebellum coordinates movement, motor learning, and some cognitive functions. Cerebellar degeneration occurs in multiple neurodegenerative ataxias and contributes to movement disorders. [1]
Apps R, Hawkes R. (2009). Cerebellar cortical organization: a one-map hypothesis. Nat Rev Neurosci. DOI:10.1038/nrn2598
Kandel ER, et al. (2021). The cerebellar microcircuit. Principles of Neural Science.
Cerebellar Purkinje Cells
Cerebellar Granule Cells
Spinocerebellar Ataxia
The study of Cerebellar Circuit Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [2]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [3]
Additional evidence sources: [4] [5] [6] [7]
De Zeeuw CI, et al. "Circuit mechanisms of cerebellar learning." Nat Rev Neurosci. Nat Rev Neurosci. 2023. ↩︎
Mauk MD, et al. "Cerebellum-dependent learning." Annu Rev Neurosci. Annu Rev Neurosci. 2022. ↩︎
Schmahmann JD. "Disorders of the cerebellum." J Neuropsychiatry Clin Neurosci. J Neuropsychiatry Clin Neurosci. 2021. ↩︎
D'Angelo E, Casali S. "The cerebellar microcircuit." Prog Brain Res. Prog Brain Res. 2023. ↩︎
Raymond JL, et al. "Roles of the cerebellum in motor control." Annu Rev Physiol. Annu Rev Physiol. 2021. ↩︎
Strata P, et al. "The olivo-cerebellar system." Cerebellum. Cerebellum. 2022. ↩︎
Apps R, et al. "Cerebellar modules and evolution." Nat Rev Neurosci. Nat Rev Neurosci. 2024. ↩︎