Central Nervous System Vascular Unit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The neurovascular unit comprises the blood-brain barrier (BBB) and its associated cellular components, critical for CNS homeostasis and increasingly implicated in neurodegenerative diseases. [1]
Components of the vascular unit: [2]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:2000029 | central nervous system neuron |
Zlokovic BV. (2011). Neurovascular pathways to neurodegeneration in AD. Nat Rev Neurosci. DOI:10.1038/nrn3114
Iadecola C. (2017). The neurovascular unit coming of age. Stroke. DOI:10.1161/STROKEAHA.117.017434
[Blood-Brain Barrier](/mechanisms/bloo- Astrocytesr) Brain Pericytes
Astrocytes Alzheimer's Disease Pathogenesis
The study of Central Nervous System Vascular Unit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [3]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [4]
Additional evidence sources: [5] [6] [7]
Zlokovic BV. "Neurovascular pathways to neurodegeneration in Alzheimer's disease." Nat Rev Neurosci. Nat Rev Neurosci. 2021. ↩︎
Attwell D, et al. "Glial and neuronal control of brain blood flow." Nature. Nature. 2022. ↩︎
Hill RA, et al. "Regional blood flow in the normal and ischemic brain." Neuropharmacology. Neuropharmacology. 2021. ↩︎
Abbott NJ, et al. "Structure and function of the blood-brain barrier." Neurobiol Dis. Neurobiol Dis. 2023. ↩︎
Sweeney MD, et al. "Vascular dysfunction in Alzheimer's disease." Acta Neuropathol. Acta Neuropathol. 2022. ↩︎
Nelson AR, et al. ["Neurovascular dysfunction and neurodegeneration." Lancet Neurol](https://doi.org/10.1016/S1474-4422(23). Lancet Neurol. 2023. ↩︎
Wardlaw JM, et al. "Blood-brain barrier failure as a core mechanism." Brain. Brain. 2024. ↩︎