Cd33 Positive Microglia is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CD33 (Siglec-3) is a sialic acid-binding immunoglobulin-like lectin expressed on microglia and other myeloid cells. CD33-positive microglia play a complex role in neurodegenerative diseases, particularly Alzheimer's disease, where genetic variants in CD33 have been associated with altered disease risk. [1]
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions. [2]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000129 | microglial cell |
| Database | ID | Name | Confidence | [3]
|----------|----|------|------------|
| Cell Ontology | CL:0000129 | microglial cell | Medium |
The CD33 rs3865444 variant has been associated with:
CD33-positive microglia influence amyloid-beta clearance through:
CD33 regulates microglial inflammatory responses:
The study of Cd33 Positive Microglia has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.