CB1 receptors are the most abundant GPCR in the brain and mediate endocannabinoid signaling.
| Property |
Value |
| Category |
Cannabinoid Receptors |
| Location |
Presynaptic terminals, Basal ganglia |
| Receptor Type |
CB1 (CNR1) |
| Signaling |
Gi-coupled, inhibitory |
- Class A: GPCR
- Seven TM domains: Typical structure
- Dimerization: Heterodimers possible
- Cerebellum: High in Purkinje cells
- Hippocampus: CA pyramidal neurons
- Basal ganglia: Motor control regions
- Gi/o inhibition: Reduces cAMP
- GIRK: Activates K+ channels
- Ca2+ channels: N-type inhibition
- Anandamide: Endogenous ligand
- 2-AG: 2-Arachidonoylglycerol
- Depolarization-induced suppression: Short-term plasticity
- Basal ganglia: Motor suppression
- Movement initiation: CB1 effects
- Parkinson's: Therapeutic potential
- Short-term: Working memory effects
- Extinction: Fear memory
- Addiction: Reward memory
- Intoxication: CB1 activation
- Tolerance: Receptor desensitization
- Dependence: Withdrawal
- Pain: Analgesic effects
- Epilepsy: Anticonvulsant
- MS: Spasticity
- Piomelli. Cannabinoid signalling (2003)
- Kano. Endocannabinoid signaling (2009)