Calcium Homeostasis In Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Calcium (Ca²⁺) is a crucial second messenger in neurons, regulating synaptic transmission, gene expression, and survival. Dysregulation is a key pathological feature in neurodegeneration. [1]
| Taxonomy | ID | Name / Label | [2]
|----------|----|---------------| [3]
| Cell Ontology (CL) | CL:4042028 | immature neuron | [4]
Berridge MJ. (2010). Calcium signalling and neuronal disease. Nat Rev Neurosci. DOI:10.1038/nrn3004
Mattson MP. (2007). Calcium and neurodegeneration. Cell Death Differ. DOI:10.1038/sj.cdd.4402251
ER Stressmechanisms/er-stress-neurodegeneration)
Alzheimer's Disease Pathogenesis
Parkinson's Disease Pathogenesis
The study of Calcium Homeostasis In Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [5]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [6]
Mattson MP. "Calcium and neurodegeneration." Aging Cell. Aging Cell. 2022. ↩︎
Stutzmann GE, Mattson MP. "Endoplasmic reticulum calcium in Alzheimer's disease." Aging Cell. Aging Cell. 2021. ↩︎
Popa-Wagner A, et al. "Calcium dysregulation in ischemic stroke." J Neurochem. J Neurochem. 2023. ↩︎
Agostinho P, et al. "Calcium dysregulation in Alzheimer's disease." Neurochem Int. Neurochem Int. 2021. ↩︎
Brini M, et al. "Neuronal calcium homeostasis." Neuropharmacology. Neuropharmacology. 2024. ↩︎
Surmeier DJ, et al. "Calcium and neuronal vulnerability in Parkinson's disease." Nat Rev Neurosci. Nat Rev Neurosci. 2022. ↩︎