Calcium dysregulation is a common mechanism in neurodegeneration, affecting neurons with specific calcium handling properties.
Calcium is crucial for neuronal function. Dysregulation leads to excitotoxicity, mitochondrial dysfunction, and cell death.
- Complex calcium dynamics
- High calcium influx
- Degeneration in multiple disorders
- LTP requires calcium
- Age-related dysregulation
- Early dysfunction in AD
- Pacemaker activity
- Calcium influx via L-type channels
- Vulnerability in PD
- High intracellular calcium
- Excitotoxicity vulnerability
- ALS-associated mutations
- NMDA receptor overactivation
- Voltage-gated calcium channels
- Ionotropic glutamate receptors
- Calbindin/Parvalbumin reductions
- Mitochondrial calcium overload
- SERCA pump dysfunction
- Plasma membrane Ca-ATPase
- Sodium/calcium exchanger
- Store-operated channels
- L-type blockers (amlodipine)
- T-type blockers
- Preferential protection
- NMDA antagonists
- AMPA modulators
- mGluR agents
- Calcium-binding proteins
- Mitochondrial protectors
- SERCA activators
- Calcium in neurodegeneration (2022)
- Calcium dysregulation in AD/PD (2021)