Area Postrema Neurons are chemoreceptor trigger zone cells located in the caudal medulla oblongata. They detect emetic substances in the blood and initiate vomiting reflexes.
| Database | ID | Name | Confidence | [1]
|----------|----|------|------------| [2]
| Cell Ontology | CL:0008044 | tanycyte of area postrema | Medium | [3]
| Taxonomy | ID | Name / Label | [4]
|----------|----|---------------| [5]
| Cell Ontology (CL) | CL:0008044 | tanycyte of area postrema |
Area Postrema Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Area Postrema neurons are chemoreceptor cells located in the caudal medulla oblongata, at the floor of the fourth ventricle. As part of the circumventricular organs, the Area Postrema lacks a complete blood-brain barrier and detects circulating toxins and hormones, making it critical for nausea/vomiting reflex and with significant implications for neurodegeneration.
| Marker | Function |
|---|---|
| NK1R | Substance P receptor |
| CGRP | Calcitonin gene-related peptide |
| TH | Tyrosine hydroxylase |
| 5-HT3R | Serotonin receptor type 3 |
| Neurokinin-1 | Substance P receptor |
Area Postrema neurons express:
The study of Area Postrema Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
S蔷 W, et al. Area Postrema dysfunction in MSA. Neurology. Area Postrema dysfunction in MSA. 2021. ↩︎
Halliday GM, et al. Early brainstem changes in PD. Brain Pathol. Early brainstem changes in PD. 2019. ↩︎
Braak H, et al. Staging of brain pathology in PD. Neurobiol Aging. Staging of brain pathology in PD. 2018. ↩︎
Del Tredici K, et al. Area Postrema and alpha-synuclein. J Neural Transm. Area Postrema and alpha-synuclein. 2022. ↩︎
Gai WP, et al. Dysautonomia and the AP. Auton Neurosci. Dysautonomia and the AP. 2021. ↩︎