Arcuate Nucleus (Arc) Expanded is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
The Arcuate Nucleus (also known as the infundibular nucleus) is a major hypothalamic nucleus located in the mediobasal hypothalamus, adjacent to the third ventricle. It plays critical roles in energy homeostasis, neuroendocrine regulation, and is importantly involved in neurodegenerative diseases. [2]
| Property | Value | [3]
|----------|-------|
| Category | Hypothalamus / Neuroendocrine |
| Location | Mediobasal hypothalamus, adjacent to median eminence |
| Function | Energy homeostasis, appetite regulation, neuroendocrine control |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Metabolic Disorders |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:1001135 | arcuate artery cell | Medium |
| Cell Ontology | CL:1001142 | arcuate vein cell | Medium |
| Cell Ontology | CL:1001213 | arcuate artery endothelial cell | Medium |
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:1001135 | arcuate artery cell |
The arcuate nucleus is a paired structure located at the base of the hypothalamus. It contains multiple neuronal populations:
NPY/AgRP Neurons
POMC Neurons
GABAergic Neurons
Dopaminergic Neurons
The study of Arcuate Nucleus (Arc) Expanded has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bjornholm M, et al. Arcuate nucleus neurons in energy homeostasis. Nat Rev Neurosci. 2017. ↩︎
Williams G, et al. Neuropeptide Y and the arcuate nucleus in neurodegeneration. Prog Brain Res. 2010. ↩︎
Morton GJ, et al. Hypothalamic regulation of energy homeostasis. J Clin Invest. 2014. ↩︎