Anti-GABA-B receptor encephalitis is a limbic encephalitis associated with small cell lung cancer and good prognosis.
Anti-GABA-BR encephalitis:
- Common in smokers
- Often SCLC-associated
- Good prognosis with treatment
- Distinct clinical features
- GABA-B receptors abundant
- CA1/CA3 involvement
- Memory dysfunction
- Limbic integration
- Emotional processing
- Variable involvement
- Less common involvement
- Ataxia possible
- Not typical
- Metabotropic GABA receptor
- Pre- and post-synaptic
- Inhibitory transmission
¶ Antibody Effects
- Receptor internalization
- Inhibitory transmission reduction
- Seizure generation
- Status epilepticus common
- Often refractory
- Early feature
- Limbic encephalitis
- Anterograde amnesia
- Often severe
- Psychiatric symptoms
- Movement disorders
- Ataxia (less common)
- SCLC management
- Often present
- Important for outcome
- Corticosteroids
- IVIG
- Second-line agents
- Anti-GABA-BR encephalitis (2022)
- Paraneoplastic encephalitis (2021)