Anterior Cingulate Cortex (Acc) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Anterior Cingulate Cortex (ACC) is a key prefrontal region involved in executive control, emotion regulation, decision-making, and pain processing.
| Property | Value |
|---|---|
| Category | Cell Types |
| Brain Region | Prefrontal Cortex |
| Neurotransmitter | Glutamate, GABA |
| Species | Human, Non-human primates, Mouse, Rat |
The ACC contains diverse neuronal populations:
The ACC orchestrates:
| Layer | Neuron Type | Function |
|---|---|---|
| II-III | Pyramidal | Cortico-cortical projections |
| V | Pyramidal (including VENs) | Subcortical projections |
| V-VI | Pyramidal | Limbic system output |
| II-VI | PV+ Interneurons | Feedforward inhibition |
| II-VI | SST+ Interneurons | Dendritic inhibition |
| Target | Approach | Disorder |
|---|---|---|
| Glutamatergic | NMDA antagonists | Depression, chronic pain |
| GABAergic | Benzodiazepines | Anxiety, sedation |
| Neuromodulation | ACC DBS | Depression, OCD |
| Transcranial | tDCS ACC | Cognitive enhancement |
The study of Anterior Cingulate Cortex (Acc) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000;4(6):215-222.
[2] Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain. 1995;118(1):279-306.
[3] Shenhav A, Botvinick MM, Cohen JD. The expected value of control: An integrative theory of anterior cingulate cortex function. Neuron. 2013;79(2):217-240.
[4] Allman JM, Hakeem A, Erwin JM. The anterior cingulate cortex: The evolution of an interface between emotion and cognition. Ann N Y Acad Sci. 2001;935(1):107-117.
[5] Rolls ET. The cingulate cortex and cingulate be used for decisions. Cingulate Neurobiology. 2019;.
[6] Holtzheimer PE, Mayberg HS. Deep brain stimulation for psychiatric disorders. Annu Rev Neurosci. 2011;34:289-307.
[7] Kniak M, Houthoofd K. Anterior cingulate cortex and response conflict. Cogn Affect Behav Neurosci. 2019;19(3):473-486.
[8] Etkin A, Egner T, Kalin R. Anxiety, disorders and the anterior cingulate cortex. Trends Cogn Sci. 2011;15(2):85-93.