Adult Neural Stem Cells is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Adult neural stem cells (NSCs) are multipotent progenitor cells that persist in the mature brain and have the capacity to generate new neurons, astrocytes, and oligodendrocytes throughout life. This process, known as adult neurogenesis, occurs primarily in two main neurogenic niches: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus[1].
Adult neural stem cells represent a reservoir of undifferentiated cells that can self-renew and differentiate into the three major neural cell types. Unlike embryonic stem cells, adult NSCs exist in a more restricted environment and have more limited differentiation potential, though they remain capable of generating multiple neural lineages[2].
The discovery of adult neurogenesis in the 1960s (by Joseph Altman) and subsequent confirmation in the 1990s revolutionized our understanding of brain plasticity. It established that the adult brain retains some capacity for regeneration and repair, challenging the long-held view that the adult mammalian brain is entirely post-mitotic[3].
The SVZ is the largest neurogenic niche in the adult brain:
The SVZ contains approximately 30,000 neural stem cells per mouse brain, producing thousands of new neurons daily in young adults[4].
The SGZ is located in the dentate gyrus of the hippocampus:
The human hippocampus produces approximately 700 new neurons per day, contributing to hippocampal plasticity and memory function[5].
Adult neural stem cells express a combination of markers:
Key pathways regulating adult NSC function:
The primary function of adult NSCs is to generate new neurons:
Newborn neurons in the adult brain:
Adult NSCs also generate glial cells:
Adult neurogenesis is significantly affected in Alzheimer's Disease:
In Parkinson's Disease:
Adult NSCs respond to brain injury:
Adult neurogenesis is implicated in mood disorders:
Adult NSCs offer therapeutic potential:
Drugs can modulate adult neurogenesis:
Therapeutic applications face challenges:
Adult neurogenesis declines with age:
Strategies to combat age-related decline:
The study of Adult Neural Stem Cells has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gage FH. Neurogenesis in the adult brain. J Neurosci. 2002;22(3):612-613. ↩︎
Götz M, Huttner WB. The cell biology of neurogenesis. Nat Rev Mol Cell Biol. 2005;6(10):777-788. ↩︎
Altman J. Are new neurons formed in the brains of adult mammals? Science. 1962;135(3509):1127-1128. ↩︎
Lois C, Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science. 1994;264(5162):1145-1148. ↩︎
Sorrells SF, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555(7696):377-381. ↩︎
Moreno-Jiménez EP, et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's Disease. Nat Med. 2019;25(4):554-560. ↩︎
Winner B, et al. Adult neurogenesis and Parkinson's Disease. Prog Brain Res. 2012;199:31-40. ↩︎
Samuels BA, Hen R. Neurogenesis and affective disorders. Eur Neuropsychopharmacol. 2015;25(8):1105-1118. ↩︎
Eriksson PS, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4(11):1313-1317. ↩︎