Accessory Optic System (Aos) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Accessory Optic System (AOS) is a collection of brainstem nuclei that process visual motion information essential for eye movements and visual stabilization. It detects retinal image motion and coordinates reflexive eye movements to maintain visual fixation.
| Property | Value |
|---|---|
| Cell Type | Multimodal sensory neurons |
| Location | Midbrain and pretectal region |
| Neurotransmitter | Glutamate, GABA |
| Primary Function | Optokinetic and vestibulo-ocular reflex |
| Diseases Affected | Progressive supranuclear palsy, PD, MSA |
The Accessory Optic System comprises several nuclei:
The AOS works with:
The study of Accessory Optic System (Aos) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Bütikofer R, King RL. The accessory optic system: a neuronal pathway for horizontal visual stabilization. Invest Ophthalmol Vis Sci. 1979;18(10):1020-1029.
[2] Simpson JI. The accessory optic system. Annu Rev Neurosci. 1984;7:13-41.
[3] Gamlin PD. The pretectum: connections and oculomotor-related roles. Prog Brain Res. 2006;151:379-405.
[4] Leigh RJ, Zee DS. The Neurology of Eye Movements. 5th ed. Oxford University Press; 2015.
[5] Pierrot-Deseilligny C, Milea D, Müri RM. Eye movement disorders. Handb Clin Neurol. 2010;95:547-568.
[6] Chen AL, Riley DE, King SA, et al. The disturbance of gaze in progressive supranuclear palsy: implications for understanding neocortical involvement. Eur J Neurol. 2010;17(3):362-369.
[7] Bhattacharyya KB, Miller M, Leventhal R. The accessory optic system in primates: a novel primate visual pathway. J Comp Neurol. 2019;527(10):1593-1610.
[8] Ilg UJ. The function of the accessory optic system (AOS). Prog Brain Res. 2008;171:281-287.