Nucleus Accumbens In Parkinson'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
The nucleus accumbens (NAc), a key component of the ventral striatum and mesolimbic dopamine system, is significantly affected in Parkinson's disease. Its involvement contributes to both motor and non-motor symptoms, particularly anhedonia and motivational deficits. [1]
| Database | ID | Name | Confidence | [2]
|----------|----|------|------------| [3]
| Cell Ontology | CL:4030051 | nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron | Medium | [4]
| Cell Ontology | CL:4030052 | nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron | Medium | [5]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4030051 | nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron |
| Compartment | Connectivity | Function |
|---|---|---|
| Core | Motor cortex, pallidum | Habit formation |
| Shell | Limbic structures | Motivation, reward |
The study of Nucleus Accumbens In Parkinson'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Carriere N, Carette D, Struys C, et al. Nucleus accumbens dysfunction in Parkinson's disease. Mov Disord. 2015. ↩︎
Robbins TW, Everitt BJ. Neurobehavioural mechanisms of reward and motivation. Curr Opin Neurobiol. 1996. ↩︎
Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD. Dopamine-dependent prediction errors underpin reward-seeking behavior in humans. Nature. 2006. ↩︎
Oishi N, Udupa K, Bucci D, et al. Reward modulation of the nucleus accumbens in Parkinson's disease. Brain. 2013. ↩︎
Averbeck BB, Lehman J, Nathanson NM. Recent advances in understanding the role of the basal ganglia. F1000Prime Rep. 2014. ↩︎