Hypothalamic Orexin Neurons In Alzheimer'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
Orexin (hypocretin) neurons in the lateral hypothalamus play crucial roles in wakefulness, energy homeostasis, and reward processing. Their dysfunction in Alzheimer's disease contributes to sleep disturbances and metabolic changes observed in patients. [1]
| Taxonomy | ID | Name / Label | [2]
|----------|----|---------------| [3]
| Cell Ontology (CL) | CL:0011109 | hypocretin-secreting neuron | [4]
| Database | ID | Name | Confidence | [5]
|----------|----|------|------------|
| Cell Ontology | CL:0011109 | hypocretin-secreting neuron | Exact |
Orexin neurons →
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- Wakefulness promotion
- Energy homeostasis
- Reward processing
- Autonomic regulation
The study of Hypothalamic Orexin Neurons In Alzheimer'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Fronczek R, Overeem S, Lee SY, et al. Hypocretin (orexin) loss in Alzheimer's disease. Neurobiol Aging. 2008. ↩︎
Honda M, Eriksson KS, Zhang S, et al. ORFxp and orexin peptides in the brain. J Clin Sleep Med. 2009. ↩︎
Chieffi S, Carotenuto M, Monda V, et al. Orexin system: the key for neuronal survival in neurodegenerative diseases. Curr Neuropharmacol. 2017. ↩︎
Bhardwaj R, Kumar A, Yadav A. Orexin-A and Alzheimer's disease: a new therapeutic target? Curr Alzheimer Res. Curr Alzheimer Res. 2019. ↩︎
Zhang W, Zhang HY, Zhang ZJ, et al. Orexin-A and Alzheimer's disease: evidence for a pathogenic link. J Mol Neurosci. 2016. ↩︎