D2 Striatal Medium Spiny Neurons In Parkinson'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
D2-expressing medium spiny neurons (D2-MSNs) in the striatum are a key population affected in Parkinson's disease. These neurons form the indirect pathway and their dysfunction contributes to the motor and non-motor manifestations of PD. [1]
| Database | ID | Name | Confidence | [2]
|----------|----|------|------------| [3]
| Cell Ontology | CL:4030047 | matrix D2 medium spiny neuron | Medium | [4]
| Cell Ontology | CL:4030049 | striosomal D2 medium spiny neuron | Medium | [5]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:4030047 | matrix D2 medium spiny neuron |
Direct Pathway (D1-MSNs): facilitates movement
Motor cortex → Striatum (D1) → GPi/SNr → Thalamus → Cortex
Indirect Pathway (D2-MSNs): suppresses movement
Motor cortex → Striatum (D2) → GPe → STN → GPi/SNr → Thalamus → Cortex
D2R activation → Gi/o protein →
↓ cAMP → PKA inhibition →
↓ DARPP-32 → PP1 activation →
Enhanced indirect pathway activity
The study of D2 Striatal Medium Spiny Neurons In Parkinson'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gerfen CR, Surmeier DJ. Modulation of striatal projection neurons by dopamine. Annu Rev Neurosci. 2011. ↩︎
Shen W, Plotkin JL, Sah V, et al. Cryptic synaptic-like signaling in striatal medium spiny neurons. J Neurophysiol. 2008. ↩︎
Fieblinger T, Graves SM, Sebel LE, et al. Cell type-specific plasticity of striatal projection neurons in levodopa-induced dyskinesia. Brain. 2014. ↩︎
Ryan MB, O'Callaghan C, Burn DJ. The role of the basal ganglia in Parkinson's disease. Ther Adv Neurol Disord. 2018. ↩︎
Calabresi P, Picconi B, Tozzi A, Di Filippo M. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Neurosci Lett. 2008. ↩︎