Serotonin 5 Ht7 Receptor Neurons is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
5-HT7 is an excitatory serotonin receptor involved in mood, sleep, circadian rhythms, and increasingly recognized in neurodegenerative disease pathophysiology. [1]
| Property | Value | [2]
|----------|-------| [3]
| Category | Serotonin Receptor Neurons | [4]
| Location | Thalamus, Hypothalamus, Hippocampus, Cerebral Cortex | [5]
| Receptor Type | 5-HT7 (HTR7 gene) | [6]
| Signaling | Gs-coupled, increases cAMP | [7]
| Expression | Neurons, astrocytes, microglia |
| Database | ID | Name | Confidence |
|---|---|---|---|
| Cell Ontology | CL:0000197 | sensory receptor cell | Medium |
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0000197 | sensory receptor cell |
The 5-HT7 receptor plays a critical role in circadian biology:
The 5-HT7 receptor has emerged as a potential therapeutic target in AD:
In PD, 5-HT7 receptors play complex roles:
PET ligands: 11CCUMI-101 for 5-HT7 visualization
Autoradiography: 3H5-CT binding studies
Serotonin 5-HT1A Receptor Neurons
Serotonin Neurotransmission
Serotonin Receptors
Alzheimer's Disease Mechanisms
Parkinson's Disease Mechanisms
The study of Serotonin 5 Ht7 Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Guscott et al. 5-HT7 receptor in CNS (2005). 2005. ↩︎
Leiser et al. 5-HT7 in cognitive function (2015). 2015. ↩︎
Mahgoub & Saransaari, 5-HT7 in neuroprotection (2019). 2019. ↩︎
Nikiforuk et al. 5-HT7 as antidepressant target (2013). 2013. ↩︎
Liu et al. 5-HT7 and Alzheimer's disease (2021). 2021. ↩︎
Benvenga et al. 5-HT7 in Parkinson's disease (2020). 2020. ↩︎
Pereira et al. 5-HT7 and circadian rhythms (2015). 2015. ↩︎